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Symbol
Name
ID

Ctla4
cytotoxic T-lymphocyte-associated protein 4
MGI:88556

Phenotype annotations related to endocrine/exocrine glands

Darker colors indicate more annotations

Human Phenotypes	Diabetes mellitus	Increased circulating free T3	Increased circulating free T4 concentration	Decreased thyroid-stimulating hormone level	Abnormality of the adrenal glands	Abnormality of the thyroid gland	Goiter	Hyperthyroidism	Graves disease	Hypothyroidism	Diabetes insipidus
Disease(s) Associated with CTLA4	Diabetes mellitus	Increased circulating free T3	Increased circulating free T4 concentration	Decreased thyroid-stimulating hormone level	Abnormality of the adrenal glands	Abnormality of the thyroid gland	Goiter	Hyperthyroidism	Graves disease	Hypothyroidism	Diabetes insipidus
Graves' disease
primary biliary cholangitis
sarcoidosis
type 1 diabetes mellitus

Mouse Phenotypes		salivary gland inflammation	abnormal thymus morphology	pancreas inflammation
Availability	Mouse Genotype	salivary gland inflammation	abnormal thymus morphology	pancreas inflammation
	Ctla4^tm1All/Ctla4^tm1All
	Ctla4^tm1Shr/Ctla4^tm1Shr
	Ctla4^tm1Saka/Ctla4^tm1Saka Foxp3^tm1(cre)Saka/Y (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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